Among the series, compound 200 showed excellent antimicrobial activity against different bacterial and fungal strains with MIC values in range of 12.5C50 g/mL . activity of a series of 5-amido-1-(2,4-dinitrophenyl)-1and methicillin resistant with MIC values of SOCS-2 25.1 M . Open in a separate window Figure 4 Structures of some pyrazole derivatives as antimicrobial compounds. A series of pyrazole derivatives were synthesized and screened for their antibacterial properties against and strains, respectively . Open in a separate window Figure 5 Structures of some pyrazole derivatives with antibacterial activity. A series of pyrazolylpyrazolines was synthesized and evaluated for their in vitro anti-microbial activity against two Gram-positive bacteria and two Gram-negative bacteria. The results schowed that the compound 162 was able to inhibit the growth of both the Gram-positive as well as Gram-negative bacteria . A series of pyrazole derivatives were prepared and screened for their anti-bacterial and antifungal activities using ampicillin and norcadine as standard drugs. All the compounds were screened for their antimicrobial activities. The results for these derivatives showed good antibacterial activity for 163 and 164 . BBhatt and Sharma synthesized a series of 3-(4-chlorophenyl)-5-((1-phenyl-3-aryl-1and in vitro anti-fungal activity, these compounds were tested against and using ampicillin and griseofulvin as standard drugs. Compound 165 was found as a potent compound against and was found to have very good activity against . 1,3,4,5-Tetrasubstituted pyrazole derivatives were synthesized and tested for anti-microbial activity against and and for their antifungal activity against and and at 100 g/mL . A series of 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties (Figure 7) were synthesized and investigated for their in vitro antimicrobial activities against various Gram-positive and Gram-negative bacteria. Compound 175 was found active against the methicillin-resistant GW841819X (MRSA) with a MIC of 2 mg/mL . A series of novel pyrazole derivatives were synthesized by Desai et al. and screened for their in vitro antibacterial activity against at 12.5 mg/mL . Pyrido[1,2-and (MRSA, QRSA) with MIC values in the range of 2C4 g/mL . Sayed and co-workers described the synthesis and antimicrobial activity of new pyrazole derivatives. The results revealed that the compound 181 showed significant antimicrobial activity against the tested GW841819X microorganisms . A series of novel 5-imidazopyrazole derivatives were synthesized and evaluated for their in vitro antibacterial activity against a panel of pathogenic strains of bacteria and fungi. Compound 182 exhibited excellent antimicrobial activity as compared with the first GW841819X line drugs . Open in a separate window Figure 7 Pyrazole derivatives showing antimicrobial activity. Pyrimidine pyrazole derivatives (Figure 8) were synthesized by Kumar et al. and screened for their antimicrobial activity against bacteria and fungi. Among all the compounds, compound 183 was found to be the most active with MIC value of 31.25 g/mL against and . Several pyrazole derivatives were synthesized and evaluated for their fungicidal activities against and and and with MIC values of 48, 46, 44 and 87 g/mL, respectively . Radi et al. reported the synthesis and antifungal activity of novel pyrazole derivatives. Compound 192 had the most potent activity against f.sp with n IC50 value of 0.055 M . A series of new pyrazole derivatives were GW841819X synthesized and evaluated for antimicrobial activity. Compound 193 showed the highest activities against tested organisms . A series of isoxazolol pyrazole carboxylate derivatives were synthesized and bioassayed in vitro against four types of phytopathogenic fungi (and Newman strain and multidrug-resistant strains (and . Elshaier et al. described the synthesis and antimicrobial activity of new series of pyrazole-thiobarbituric acid derivatives. Compound 196 was the most active against with MIC = 4 g/L, and exhibited the best activity against and with MIC = 16 g/L . A series of novel pyrazole-5-carboxylate derivatives containing a and in MIC = 4 g/L . Several new pyrazole derivatives incorporating a thiophene moiety were synthesized and evaluated for their antibacterial and antifungal activities. The results showed that compound 198 revealed a high degree of antibacterial activity towards and inhibition effects against . Open in a separate window Figure 9 Pyrazole derivatives with antimicrobial activity. A series of novel pyrazole amide derivatives (Figure 10) were synthesized and evaluated in vivo for their antifungal activity against Trow, (Mont.) De Bary, and Trow at a GW841819X concentration of 100 g/mL . Nagamallu et al. synthesized a series of novel coumarin pyrazole hybrids were synthesized and evaluated for antimicrobial activities. Among the series, compound 200 showed excellent antimicrobial activity against different bacterial and fungal strains with MIC values in range of 12.5C50 g/mL ..